The San Francisco 49ers head into SoFi Stadium to face the Los Angeles Rams in Week 3 with a notable list injuries. Among ...

The last time the 49ers played a game without Christian McCaffrey and Deebo Samuel, they scored 23 points and lost to the Seahawks. That was back in 2021 when Jimmy Garoppolo was the quarterback ...

The loss to the Minnesota Vikings is getting worse for the San Francisco 49ers. Star wide receiver Deebo Samuel sustained a calf strain in the game and is expected to be out for a "couple weeks ...

"After the San Francisco 49ers dispatched the New York Jets with relative ease in Week 1, the belief by many was that the team would experience similar success in Week 2 against the Minnesota Vikings.

View pregame photos from the San Francisco 49ers Week 2 matchup vs. the Minnesota Vikings at U.S. Bank Stadium, presented by SAP. 1 / 43 WR Jauan Jennings ...

The San Francisco 49ers and Los Angeles Rams play on Sunday, Sept. 22, at SoFi Stadium in a game on the NFL Week 3 schedule. Which team will win the Week 3 NFL game? The 49ers are a 7.5-point ...

Just two games into the season, the Rams (0-2) are approaching desperate times as they prepare to face the San Francisco 49ers (1-1) Sunday afternoon at SoFi Stadium. The list of issues thus far for ...

The San Francisco 49ers are at risk of being without another star offensive player for Week 3. Tight end George Kittle is experiencing hamstring tightness and did not practice Thursday ...

San Francisco 49ers rookie wide receiver Ricky Pearsall was shot Saturday afternoon in an attempted robbery in the Union Square area, San Francisco Mayor London Breed's office confirmed.

Minnesota Vikings wide receiver Justin Jefferson's 97-yard touchdown reception in the Vikings' 23-17 win over the San Francisco 49ers was the longest scoring play of Week 2 through Sunday.